Blar i forfatter "Kildalsen, Hanne"

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    • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

      Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
      DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...

    • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

      Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...

    • Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 

      Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
      The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood. Here we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known regulator of the ERK and p38 MAPKs, is unique amongst ...